
Sluggy Freelance is one of the oldest and most consistent web comics still in publication.
The Book of Biff is a classic one-panel comic without any backstory. My favorites include #219 Brick and #249 Flour.
A an independent print comic turned weekly webcomic, Pride High is a strongly-written teen-superhero scenario.
Giant bees, devils vs faeries, and zombies, Scary Go Round is always a strange look at the world.
A guilty pleasure of a teen-angst comic.
Eagle burgers, Drunk Jesus, Weedmaster P, and digging Christopher Columbus from the grave. Overcompensating lives up to its name.
The weekly scripts of professional cartoonist Carol Lay.
An exercise in minimalism, Daily Dinosaur Comics features the same three dinosaurs in the same positions week, after week, after week. The magic is in the dialog which ranges from Checkov's gun, to impossible sexual orientations, to conversations with god.